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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: Another major advance is the observation of immunological responses associated with nano-enabled hyperthermiaThis perspective first discusses the temperature-gradient and the spatially-structured immunologicallandscape in solid tumors receiving nano-enabled hyperthermia.the discussion about underlying mechanism such as immunogenic cell death, which initiates a profound immunologicalactivation as a viable therapeutic principle, we further discussed the tumor type-specific complexity in the immunological

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 91-95 doi: 10.1007/s11684-009-0011-z

Abstract: To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injuryadopted, among which, 50 mice were given intraperitoneal injection with BCG and LPS to establish an immunologicalThis experiment established the immunological liver injury model successfully and found that FGL hasa remarkably protective effect on this kind of immunological hepatic injury.

Keywords： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

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Emerging immunological strategies: recent advances and future directions

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 805-828 doi: 10.1007/s11684-021-0886-x

Abstract: Immunotherapy plays a compelling role in cancer treatment and has already made remarkable progress. However, many patients receiving immune checkpoint inhibitors fail to achieve clinical benefits, and the response rates vary among tumor types. New approaches that promote anti-tumor immunity have recently been developed, such as small molecules, bispecific antibodies, chimeric antigen receptor T cell products, and cancer vaccines. Small molecule drugs include agonists and inhibitors that can reach the intracellular or extracellular targets of immune cells participating in innate or adaptive immune pathways. Bispecific antibodies, which bind two different antigens or one antigen with two different epitopes, are of great interest. Chimeric antigen receptor T cell products and cancer vaccines have also been investigated. This review explores the recent progress and challenges of different forms of immunotherapy agents and provides an insight into future immunotherapeutic strategies.

Keywords： cancer immunotherapy     bispecific antibodies     small molecules     chimeric antigen receptor T therapy     cancer vaccines    

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The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 291-298 doi: 10.15302/J-FASE-2014033

Abstract: government is strengthening research on improvement and reconstruction of the ecological system and landscapeIt is suggested that the reconstruction of landscape should be conducted by step by step regionalizationThe first level regionalization results of reconstruction of landscape are discussed.

Keywords： reconstruction of landscape     ecological system     the northwest area of China     science and technology action    

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Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 498-502 doi: 10.1007/s11709-010-0096-0

Abstract: the laws of light cognitive impact and the solution to the problem on application of light color in landscapeThis paper took chromatic-light-induced-emotion towards architectural wall coatings in landscape as the, the study successfully extracted light emotional factors and the rule of predictability to assist landscape

Keywords： landscape illumination     architectural wall coatings     chromatic-light emotion     quantitative research    

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FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 63-74 doi: 10.15302/J-FASE-2021427

Abstract:

There is a growing demand for high-quality agricultural products and more countries have adopted landscape

Keywords： ecosystem services / flowering plants / natural enemies / nectar / pollen    

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of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 269-278 doi: 10.1007/s11783-014-0672-y

Abstract: Soil moisture variability in natural landscapes has been widely studied; however, less attention has been paid to its variability in the urban landscapes with respect to the possible influence of texture stratification and irrigation management. Therefore, a case study was carried out in the Beijing Olympic Forest Park to continuously monitor the soil in three typical profiles from 26 April to 11 November 2010. The texture stratification significantly affected the vertical distribution of moisture in the non-irrigated profile where moisture was mostly below field capacity. In the profile where irrigation was sufficient to maintain moisture above field capacity, gravity flow led to increased moisture with depth and thus eliminated the influence of texture. In the non-irrigated sites, the upper layer (above 80 cm) exhibited long-term moisture persistence with the time scale approximating the average rainfall interval. However, a coarse-textured layer weakened the influence of rainfall, and a fine-textured layer weakened the influence of evapotranspiration, both of which resulted in random noise-like moisture series in the deeper layers. At the irrigated site, frequent irrigation neutralized the influence of evapotranspiration in the upper layer (above 60 cm) and overshadowed the influence of rainfall in the deeper layer. As a result, the moisture level in the upper layer also behaved as a random noise-like series; whereas due to deep transpiration, the moisture of the deep layer had a persistence time-scale longer than a month, consistent with characteristic time-scales found for deep transpiration.

Keywords： distribution     moisture temporal variation     texture stratification     irrigation     meteorological forcing     urban landscape    

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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract:

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies.

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy    

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Computational design of heterogeneous catalysts and gas separation materials for advanced chemical processing

Huaiwei Shi, Teng Zhou

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 49-59 doi: 10.1007/s11705-020-1959-0

Abstract: This article selectively focuses on two important process functional materials, namely heterogeneous

Keywords： heterogeneous catalyst     gas separation     solvent     porous adsorbent     material screening and design    

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nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1564-1

Abstract:

● A new model for bloom control in open land scape water was constructed.

Keywords： Reclaimed water landscape     Algal bloom     Nitrogen and phosphorus     Hydraulic retention time     Threshold    

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Application of heterogeneous catalysis to biodiesel synthesis using microalgae oil

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1343-9

Abstract:

• Microalgae oil application for biodiesel synthesis is discussed.

Keywords： Biodiesel     Heterogeneous catalysis     Transesterification     Microalgae oil    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: This study aimed to depict the genetic landscape of Chinese PCNSLs.Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Taking Warning from the Eastern Part Elegant Landscape Maturing Slowly——On Landscape Architectural Development

Meng Zhaozhen

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 56-58

Abstract:

Elegant landscape will mature slowly.

Keywords： urbanization process     scenic and historical places     urban parks and gardens    

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Social media and mobility landscape: Uncovering spatial patterns of urban human mobility with multi source

Yilan Cui, Xing Xie, Yi Liu

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1068-1

Abstract:

Check-in and survey data are explored to identify personal activity-specific places.

Ways for detecting and moderating sample bias of Weibo check-in data is proposed.

A graphic representation of urban activity intensity in Beijing, China is presented.

The potential application of Weibo check-in data for urban analysis is introduced.

Keywords： Social media     Human mobility     Population bias     Sample reconstruction     Data integration    

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Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 4,   Pages 566-583 doi: 10.1007/s11709-023-0905-x

Abstract: The analysis of the bearing capacity of strip footings sited near an excavation is critical in geotechnics. In this study, the effects of the geometrical features of the excavation and the soil strength properties on the seismic bearing capacity of a strip footing resting on an excavation were evaluated using the lower and upper bounds of the finite element limit analysis method. The effects of the setback distance ratio (L/B), excavation height ratio (H/B), soil strength heterogeneity (kB/cu), and horizontal earthquake coefficient (kh) were analyzed. Design charts and tables were produced to clarify the relationship between the undrained seismic bearing capacity and the selected parameters.

Keywords： excavation     finite element limit analysis     heterogeneous soil     strip footing     undrained bearing capacity    

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Title Author Date Type Operation

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Journal Article

Emerging immunological strategies: recent advances and future directions

Journal Article

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

Journal Article

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

Journal Article

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

Journal Article

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Journal Article

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Computational design of heterogeneous catalysts and gas separation materials for advanced chemical processing

Huaiwei Shi, Teng Zhou

Journal Article

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

Journal Article

Application of heterogeneous catalysis to biodiesel synthesis using microalgae oil

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Taking Warning from the Eastern Part Elegant Landscape Maturing Slowly——On Landscape Architectural Development

Meng Zhaozhen

Journal Article

Social media and mobility landscape: Uncovering spatial patterns of urban human mobility with multi source

Yilan Cui, Xing Xie, Yi Liu

Journal Article

Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

Journal Article